|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Vomiting, recurrent
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
A neonate with recurrent vomiting and generalized hypotonia diagnosed with a deficiency of dihydropyrimidine dehydrogenase.
|
17065071 |
2006 |
|
Upward slant of palpebral fissure
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Upper Aerodigestive Tract Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.
|
19020767 |
2008 |
|
Undifferentiated carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There were no significant correlations between TS/DPD levels and other clinicopathological factors, except for low DPD mRNA levels in undifferentiated carcinoma.
|
10697632 |
2000 |
|
Tumor Progression
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Our results also revealed a disturbed transcription of Per1 during tumor progression, which might be the cause for disrupted daily oscillation of DPD in undifferentiated colon carcinoma cells.
|
17699798 |
2007 |
|
Tumor Progression
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Increases of the DPD mRNA level in cancerous tissue seem to reflect tumor progression.
|
12095978 |
2002 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Immunohistochemical evaluation of TS and DPD in UTUC human samples revealed that TS expression was significantly associated with stage, grade, and lymphovascular invasion and DPD expression was significantly associated with grade.
|
22998564 |
2012 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
A high expression of 5-FU factors was detected: orotate phosphoribosyltransferase: differentiated cases (P = 0.0137), lower T factor (P = 0.0411); dihydropyrimidine dehydrogenase: nerve invasion (P = 0.0188), lymph node recurrence (P = 0.0253); TS, positive N factor (P = 0.0061).
|
20944490 |
2010 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Genomic rearrangements in DPYD, rather than aberrant DPD protein levels, reflect a distinct tumour profile associated with prolonged time to progression upon first-line chemotherapy in TNBC.
|
24104963 |
2013 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Genomic rearrangements in DPYD, rather than aberrant DPD protein levels, reflect a distinct tumour profile associated with prolonged time to progression upon first-line chemotherapy in TNBC.
|
24104963 |
2013 |
|
Transthyretin cardiac amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Either 99mTechnetium diphosphonate (Tc-DPD) or pyrophosphate (Tc-PYP) scintigraphy plays a relevant role in diagnosing transthyretin cardiac amyloidosis (CA), and labeled radiotracers have been extensively studied in diagnosing CA.
|
28537040 |
2019 |
|
Thymoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The combined use of measurements of TS and DPD mRNA levels using real-time RT-PCR analyses may provide an indication of the selective cytoxicity of 5-FU on thymoma.
|
12616366 |
2003 |
|
Thymic Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also conducted in vitro study of TS, OPRT and DPD expression using thymic carcinoma, thymic tumor and thymic fibroblast cell lines.
|
21550686 |
2011 |
|
Thrombocytopenia
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
DPYD*9A carries were found to be at higher risk for HFS, diarrhoea and thrombocytopenia when compared to patients with wild allele.
|
31653159 |
2019 |
|
Thrombocytopenia
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
The DPYD*2A variant statistically significantly associated with the specific AEs nausea/vomiting (P = .007) and neutropenia (P < .001), whereas D949V statistically significantly associated with dehydration (P = .02), diarrhea (P = .003), leukopenia (P = .002), neutropenia (P < .001), and thrombocytopenia (P < .001).
|
25381393 |
2014 |
|
Sunken eyes
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Stomatitis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Two rare DPYD variants were associated with increased toxicity (Asp949Val with neutropenia, nausea and vomiting, diarrhoea and infection; IVS14+1G>A with lethargy, diarrhoea, stomatitis, hand-foot syndrome and infection; all ORs > 3).
|
30114658 |
2018 |
|
Stomatitis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
It was lower DPD activity that responsible for the relatively higher incidence of bone marrow hypocellular, diarrhea, and oral mucositis in the C<sub>SN-38 1.5 h</sub> > 50.24 ng/ml and C<sub>SN-38 49 h</sub> > 15.25 ng/ml subsets.
|
28278081 |
2017 |
|
Stomatitis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The incidence of bone marrow suppression, diarrhea, and oral mucositis was high in patients with low DPD mRNA expression.
|
25388847 |
2015 |
|
Stomach Neoplasms
|
0.320 |
AlteredExpression
|
group |
LHGDN |
Comparative analysis of thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in gastric and colorectal cancers.
|
15069545 |
2004 |
|
Stomach Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
Recent studies showed that the mutations in EGFR is associated with high expression of dihydropyrimidine dehydrogenase, which is an inactivating and rate-limiting enzyme for fluoropyrimidine, and suggested that the combination of chemotherapy with fluoropyrimidine and EGFR-targeting agents is effective against EGFR-overexpressing gastric tumors, while ANXA3 overexpression confers resistance to tyrosine kinase inhibitors targeting the EGFR pathway.
|
26475168 |
2015 |
|
Stomach Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
The expression profiles of orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in gastric cancer and their clinical significance.
|
17089033 |
2006 |
|
Stomach Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients.
|
15837757 |
2005 |
|
Stomach Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer.
|
18652704 |
2008 |